This review summarises and critically examines methods used to generate utilities for child and adolescent health states in different patient groups in previous NICE technology appraisals.
We searched for all NICE Technology Appraisal (TA) and NICE Highly Specialised Technology (HST) appraisals where the licensed indication for the technology included people under 18 years. The review includes 31 NICE appraisals. The review found limited use of child and adolescent population-specific measures to generate health state utility values for children and adolescents in technology appraisals submitted to NICE. Often appraisals use an adult specific measure to reflect the health of children and adolescents.
A review of the psychometric performance of child and adolescent preference-based measures used to generate utility values for children
The report reviews the psychometric performance of the main child and adolescent preference-based measures that could be used in submissions to NICE: AQoL-6D; CHU9D; EQ-5D-Y; HUI2; and HUI3.
The report is a review of available published evidence on the psychometric performance of a selection of child and adolescent-specific preference-based measures. From the current evidence, EQ-5D-Y has the largest amount of evidence of good psychometric performance in proportion to the number of studies that have examined its psychometric performance. The majority of the evidence related to EQ-5D-Y is based on dimensions. The CHU9D is assessed in fewer studies, but the majority of studies find evidence of good psychometric performance. The evidence for HUI2 and HUI3 are more mixed, and for AQoL-6D the evidence is based on only one study